Robotic stereotactic radiosurgery for intracranial meningiomas in elderly patients: assessment of treatment efficacy and safety

• DOI: 10.3389/fonc.2024.1329696
• Publication Date: 2024-01-29T14:34:06Z
• Authors: Anton Früh; Bohdan Bodnar; Marcel Nachbar; Julia Gradhand; Goda Kalinauskaite; Kerstin Rubarth; Peter Truckenmueller; David Kaul; Daniel Zips; Peter Vajkoczy; Carolin Senger; Güliz Acker
• Keywords: Cyberknife

Purpose Stereotactic radiosurgery (SRS) has been increasingly used to treat intracranial pathologies in elderly patients. The treatment efficiency of SRS demonstrated meningiomas, with excellent local control. We aimed analyze the safety robotic patients meningiomas. Methods searched for suspected WHO °I meningioma ≥ 60 years old, who underwent CyberKnife (CK) from January 2011 December 2021. Tumor localization was categorized using “CLASS” algorithmic scale. response evaluated Response Assessment Neuro-Oncology (RANO) criteria Adverse effects were graded Common Terminology Criteria Events (CTCAE) version 5.0 and a cox regression performed investigate possible predictors. Results identified 82 102 CK-treated lesions that matched first SRS. median age 70 [IQR 64-75] years, 24.3% aged > 75 years. Multiple (up six) treated 14.1% SRS-sessions. A previous surgery 57.3% lesions, time interval 41 10 – 58] months between initial surgical procedure treatment. In 47.9% cases, CLASS 3 meningiomas at high-risk locations irradiated. Single fraction applied 62.5% while remaining cases multi-session three five fractions used. During follow-up period 15.9 months, lesion size progression observed cases. Karnofsky Performance Status (KPS) declined by 20 points four occurred 13 patients, only had CTCAE ≥2 toxicities. Hereby one these toxicities persistent. occurrence complications independent age, planned target volume (PTV), localization, before Conclusion data indicates is safe, efficient, convenient modality meningioma, even