Review of tracer kinetic models in evaluation of gliomas using dynamic contrast-enhanced imaging

• DOI: 10.3389/fonc.2024.1380793
• Publication Date: 2024-06-14T04:35:09Z
• Authors: Jianan Zhou; Zujun Hou; Chuanshuai Tian; Zhengyang Zhu; Meiping Ye; Sixuan Chen; Huiquan Yang; Xin Zhang; Bing Zhang
• Keywords: Dynamic Contrast-Enhanced MRI

Glioma is the most common type of primary malignant tumor central nervous system (CNS), and characterized by high malignancy, recurrence rate poor survival. Conventional imaging techniques only provide information regarding anatomical location, morphological characteristics, enhancement patterns. In contrast, advanced such as dynamic contrast-enhanced (DCE) MRI or DCE CT can reflect tissue microcirculation, including vascular hyperplasia vessel permeability. Although several studies have used to evaluate gliomas, results data analysis using conventional tracer kinetic models (TKMs) Tofts extended-Tofts model (ETM) been ambiguous. More Brix’s two-compartment (Brix), homogeneity (TH) distributed parameter (DP) developed, but their application in clinical trials has limited. This review attempts appraise issues on glioma TKMs, ETM model, highlight advancement provides insights value management more TKMs.