The efficacy and safety of local 5-aminolevulinic acid-based photodynamic therapy in the treatment of cervical high-grade squamous intraepithelial lesion: a single center retrospective observational study

• DOI: 10.3389/fonc.2024.1390982
• Publication Date: 2024-04-16T05:01:11Z
• Authors: Jing Qian; Yahui Wang; Guihong Wu; Junlei Lu; Liping Sun; Song Xu
• Keywords: Squamous intraepithelial lesion; Cervical canal

Background Typical treatments for cervical high-grade squamous intraepithelial lesion (HSIL) are invasive procedures. However, these procedures often come with several severe side effects, despite their positive effects on HSIL. 5-aminolevulinic acid photodynamic therapy (ALA-PDT) is a non-invasive treatment that has been successfully used to treat low-grade (LSIL). In this study, we aimed further investigate the clinical efficacy and safety of ALA-PDT in patients Methods A total 40 aged 20 - 41 years HSIL high-risk Human Papilloma Virus (HR-HPV) infections were enrolled retrospective study from January 2019 December 2022. Patients treated six times at intervals 7–14 days. Three months after treatment, was evaluated through HPV genotyping cytology examination. If cytological result worse than ASC -US, patient underwent colposcopy-directed biopsy immediately. Otherwise, would receive rigorous follow-up observation. Results receiving 65% (26/40) our center showed complete regression (cytological result: normal; HR-HPV: negative). This rate increased 82.5% (33/40) 12-month follow-up. None experienced disease progression therapy. The risk persistent HR-HPV infection 32.5% (13/40) 3-month ALA-PDT. Multivariate analyses identified canal involvement as an independent factor treatment. During ALA-PDT, there no reports adverse reactions. Only limited number slight discomfort symptoms. Conclusion safe effective noninvasive infections. It particularly suitable young women, who have confirmed demand fertility protection. if still either ASC-US and/or infection, observation considered her. Cervical