Host-gut microbiota derived secondary metabolite mediated regulation of Wnt/β-catenin pathway: a potential therapeutic axis in IBD and CRC

• DOI: 10.3389/fonc.2024.1392565
• Publication Date: 2024-04-19T04:57:31Z
• Authors: Sushma S. Kumar; Ashna Fathima; Preeti Srihari; Trinath Jamma
• Keywords: Dysbiosis; Lamina propria

The intestinal tract encompasses one of the largest mucosal surfaces with a well-structured layer epithelial cells supported by network underlying lamina propria immune maintaining barrier integrity. commensal microflora in this environment is major contributor to such functional outcomes due its prominent role production secondary metabolites. Of several known metabolites gut microbial origin, as Short Chain Fatty Acids (SCFAs), amino acid derivatives, etc., bile acids (BAs) are also shown exhibit pleiotropic effects homeostasis addition their canonical dietary lipid digestion. However, dysbiosis intestine causes an imbalance diversity, resulting alterations functionally effective concentration these metabolites, including BAs. This often leads aberrant activation and associated signaling pathways, causing inflammation. Sustained pathways drives unregulated cell proliferation and, when coupled genotoxic stress, promotes tumorigenesis. Here, we aimed discuss along BAs immune-gut regulation inflammation-driven tumorigenesis emphasis on classical Wnt/β-Catenin pathway colon cancer.