Case report: Pulmonary sarcomatoid carcinoma demonstrating rapid growth on follow-up CT

• DOI: 10.3389/fonc.2024.1393203
• Publication Date: 2024-07-08T04:32:05Z
• Authors: Li Tu; Hong Xie; Lianshan Zhan; Yushi Yang; Tingting Chen; Na Hu; Xiaojun Du; Shi Zhou
• Keywords: Sarcomatoid Carcinoma; Nodule (geology); Chest radiograph

Background The tumor growth rate and volume doubling time are crucial parameters in diagnosing managing lung lesions. Pulmonary sarcomatoid carcinoma (PSC) is a unique highly malignant subtype of cancer, with limited documentation on its feature. This article aims to address the gap knowledge regarding PSC’s patterns by describing characteristics confirmed case using computed tomography, thereby enhancing understanding this rare disease. Case presentation A 79-year-old man was transferred our center presenting mild cough, blood-tinged sputum, nodule left upper lobe. Chest CT revealed solid follow-up ten days later showed significant increase size nodule, accompanied ground-glass opacity surrounding lung. rapid preoperative suggested non-neoplastic lesion, intraoperative frozen pathology also considered possibility tuberculosis. Subsequently, apical-posterior segment (S1 + 2) resection performed. Postoperative diagnosis pulmonary extensive giant cell necrosis. Immunohistochemistry indicated approximately 60% PD-L1 positive genetic testing MET mutation. patient discharged oral crizotinib targeted therapy, his condition remained stable postoperatively. currently undergoing regular at hospital, no evidence distant metastasis or recurrence. Conclusion can exhibit imaging, PSC should be differential for lesions that present fast rate. Timely appropriate treatment may lead good prognosis.