Clinical experience with adaptive MRI-guided pancreatic SBRT and the use of abdominal compression to reduce treatment volume

• DOI: 10.3389/fonc.2024.1441227
• Publication Date: 2024-08-09T04:50:42Z
• Authors: William S. Ferris; Benjamin George; Kristin A. Plichta; Joseph M. Caster; Daniel E. Hyer; Blake R. Smith; Joel J. St-Aubin
• Keywords: 03 medical and health sciences; SBRT; 0302 clinical medicine; Unity; Oncology; pancreatic cancer; adaptive; Neoplasms. Tumors. Oncology. Including cancer and carcinogens; MR-linac; compression; RC254-282

IntroductionThis work presents a method to treat stereotactic body radiation therapy (SBRT) for pancreatic cancer on a magnetic resonance-guided linear accelerator (MR-linac) using daily adaptation, real-time motion monitoring, and abdominal compression.MethodsThe motion management and treatment planning process involves a magnetic resonance imaging (MRI) simulation with cine and 3D images, a computed tomography (CT) simulation with a breath-hold CT and a 4DCT, pre-treatment verification and planning MRI, and intrafraction MRI cine images.ResultsThe results from 26 patients were included in this work. Our motion management process results in consistent motion analysis on the CT simulation, MRI simulation, and each treatment fraction. The liver dome was found to be an overestimate of tumor superior/inferior (SI) motion for most patients. Adding compression reduced SI liver dome motion by 6.2 mm on average. Clinical outcomes are similar to those observed in the literature.ConclusionsIn this work, we demonstrate how pancreatic SBRT can be successfully treated on an MR-linac using abdominal compression. This allows for an increased duty cycle compared to gating and/or breath-hold techniques.