Vitamin D receptor is associated with prognostic characteristics of breast cancer after neoadjuvant chemotherapy—an observational study

• DOI: 10.3389/fonc.2024.1458124
• Publication Date: 2024-10-01T14:10:09Z
• Authors: Joanna Streb; Agnieszka Łazarczyk; Przemysław Hałubiec; Anna Streb-Smoleń; Julita Ciuruś; Magdalena Ulatows...; Martyna Trzeszcz; Kamil Konopka; Diana Hodorowicz-...; Joanna Szpor
• Keywords: breast cancer; Oncology; vitamin D receptor; residual cancer burden; Neoplasms. Tumors. Oncology. Including cancer and carcinogens; vitamin D; pathological response; RC254-282; neoadjuvant chemotherapy

Background Breast cancer (BC) is the most commonly diagnosed malignant tumor in women. The disease and its subsequent treatment pose a serious burden on quality of life patients. Neoadjuvant chemotherapy (NAC) has become one crucial strategies for management BC. Since identification vitamin D receptor (VDR) mammary tissues, extensive mechanistic research been conducted function. expression VDR BC cells microenvironment could be new prognostic factor after NAC. Patients Methods This observational, single-center study compared data from clinical histopathological records 111 female subjects with different cellular tissue components breast specimens obtained surgery was evaluated using an immunoreactive score assigned immunohistochemistry. Intergroup comparisons logistic regression were used to identify associations between clinicopathological features Results We found that associated various (i.e., age, menopausal status, NAC cycle number) characteristics significance, such as residual class. Logistic analysis revealed nuclei cytoplasm surrounding normal predicted vascular invasion lymph node involvement. Conclusions their related