Long term survival following cryoablation with adjuvant Toripalimab for anorectal malignant melanoma: a case report

• DOI: 10.3389/fonc.2025.1465645
• Publication Date: 2025-01-24T05:21:49Z
• Authors: Xuejun Jiang; Zujin Ji; Peng Li; Fangjun Yuan; Xinyi Lei; Yong Yang
• Keywords: Cryoablation; Cryosurgery; Abdominoperineal resection; Regimen; Adjuvant Therapy

Background Anorectal malignant melanoma is a rare subtype of with poor prognosis. Despite this, some patients decline Miles’ operation due to the sigmoid colostomies that follow abdominoperineal resections in cases anorectal melanoma. Case report We case an 80-year-old woman diagnosed who underwent cryosurgery accompanied by adjuvant PD-1 therapy maintain anal sphincter function. The results indicated we successfully achieved goal preservation and therapeutic efficacy. patient derived significant benefits from cryoablation treatment. Conclusions Ultrasound-guided trans-anal cryoablation, when combined therapy, offers novel treatment approach for Our have confirmed advantages this regimen, particularly those desiring retain Further studies are required substantiate efficacy ultrasound-guided Toripalimab elucidate its underlying mechanisms.