Prognostic factors for employment outcomes in patients with a history of childhood-onset drug-resistant epilepsy

• DOI: 10.3389/fped.2023.1173126
• Publication Date: 2023-07-28T17:06:00Z
• Authors: Yuto Arai; Tohru Okanishi; Hisashi Noma; Sotaro Kanai; Tatsuya Kawaguchi; Hiroshi Sunada; Ayataka Fujimoto; Yoshihiro Maegaki
• Keywords: Levetiracetam

The employment outcomes of childhood-onset drug-resistant epilepsy (DRE) has not been studied enough. aim this retrospective cohort study is to investigate the DRE in June 2022 and identify risk factors associated with non-employment.The sample consisted 65 participants ≥18 years age a history DRE. Fifty (77%) were salaried employees 15 (23%) non-employed. Clinical psychosocial information evaluated for calculating relative (RR) non-employment.Regarding medical factors, lower IQ [RR, 0.645; 95% confidence interval (CI), 0.443-0.938; p = 0.022] was positively employment. In contrast, at follow-up (RR, 1.046; CI, 1.009-1.085; 0.014); number ASMs 1.517; 1.081-2.129; 0.016); use medications such as phenobarbital 3.111; 1.383-6.997; 0.006), levetiracetam 2.471; 1.056-5.782; 0.037), topiramate 3.576; 1.644-7.780; 0.001) negatively Regarding factor, initial workplace support facilities 0.241; 0.113-0.513; < complication psychiatric disorder symptoms 6.833; 2.141-21.810; educational graduating schools special needs education 0.148; 0.061-0.360; employment.Specific medical, psychosocial, may influence Paying attention ASMs' side effects, adequately preventing complications symptoms, providing an environment suitable each patient condition would promote fine working status people