Long-term outcomes of liver transplantation for biliary atresia and results of policy changes: over 20 years of follow-up experience

• DOI: 10.3389/fped.2023.1242009
• Publication Date: 2024-03-01T04:20:06Z
• Authors: Yiyoung Kwon; Yoon Ji Ahn; Jaehun Yang; Eun Sil Kim; Yon Ho Choe; Sanghoon Lee; Mi Jin Kim
• Keywords: Immunosuppression; Liver disease

Objective Biliary atresia (BA) patients develop chronic liver disease after the Kasai operation and are eventually indicated for transplantation (LT). The purposes of this study were to analyze long-term outcomes LT risk factors that affect complications reduce graft failure. Study design Overall, 145 pediatric who underwent between June 1996 2020 a diagnosis BA included. We performed retrospective analysis medical records evaluated patient survival, cumulative incidence complications, factors, results policy changes. Results Patient survival rates in over 20 years 95.8% 91.0%, respectively. Post-transplantation lymphoproliferative was frequently observed early period immunosuppression within first 1–2 LT. cholangitis rejection steadily increased time. Weight-to-portal vein size as factor bile duct strictures (OR = 12.82, p 0.006 OR 16.54, 0.015, respectively). When using 2013 reference point, split indication expanded group received had significantly lower time compared with before ( 0.006). Conclusion This revealed differences prevalence complications. evaluation weight-to-duct or vessel is more important considering than graft-to-recipient weight ratio. Survival may have been altered by change affects donor type ratio transplantation.