Astragalin Inhibits the Proliferation and Migration of Human Colon Cancer HCT116 Cells by Regulating the NF-κB Signaling Pathway

• DOI: 10.3389/fphar.2021.639256
• Publication Date: 2021-04-19T11:21:22Z
• Authors: Min Yang; Wen-Yun Li; Jing Xie; Zi-Lin Wang; Yan-Long Wen; Cun-Chao Zhao; Liang Tao; Ling-Fei Li; Yang Tian; Jun Sheng
• Keywords: Astragalin; Caspase 8

Astragalin is a flavonoid found in variety of natural plants. It has anti-inflammatory, anti-oxidant effects and inhibited against several malignant tumor cell types. However, its on colon cancer the molecular mechanisms have remained to be elucidated. In this study, we evaluated inhibitory effect astragalin proliferation migration human HCT116 cells vitro vivo . Furthermore, elucidated mechanism these effects. The results showed that significantly diffusion by induced apoptosis (by modulation Bax, Bcl-2, P53, caspase-3, caspase 6, 7, 8, 9 protein express) cycle arrest Cyclin D1, E, P21, P27, CDK2, CDK4 express). Moreover, suppressed inhibiting expression matrix metalloproteinases (MMP-2, MMP-9). addition, downregulated key proteins NF-κB signaling pathway transcriptional activity P65 stimulated with inflammatory cytokines TNF-α, thereby growth Our further investigations unveiled gavage reduced xenograft nude mice, experiments was related decreased apoptotic tissues pathway. summary, our indicated inhibits via Therefore, maybe become potential plant-derived antitumor drug for cancer.