Protective Effect of Fluorofenidone Against Acute Lung Injury Through Suppressing the MAPK/NF-κB Pathway

• DOI: 10.3389/fphar.2021.772031
• Publication Date: 2021-12-20T06:45:52Z
• Authors: Xin Lv; Tingting Yao; Rongling He; Yijun He; Mengyu Li; Yuanyuan Han; Yan Zhang; Lingzhi Long; Guoliang Jiang; Xiaoyun Cheng; Yanyun Xie; Ling Huang; Zhangzhe Peng; Gaoyun Hu; Qianbin Li; Lijian Tao; Jie Meng
• Keywords: Proinflammatory cytokine

Acute lung injury (ALI) is a severe disease that presents serious damage and excessive inflammation in lungs with high mortality without effective pharmacological therapy. Fluorofenidone (AKFPD) novel pyridone agent has anti-fibrosis, anti-inflammation, other activities, while the effect of fluorofenidone on ALI unclarified. Here, we elucidated protective effects underlying mechanism lipopolysaccharide (LPS)-induced ALI. In this study, alleviated tissue structure reduced mortality, decreased pulmonary inflammatory cell accumulation level cytokines IL-1β, IL-6, TNF-α bronchoalveolar lavage fluid, attenuated apoptosis LPS-induced mice. Moreover, could block LPS-activated phosphorylation ERK, JNK, P38 further inhibited IκB P65. These results suggested can significantly contrast through suppressing activation MAPK/NF-κB signaling pathway, which indicates be considered as therapeutic candidate for