Shexiang Tongxin Dropping Pills Promote Macrophage Polarization-Induced Angiogenesis Against Coronary Microvascular Dysfunction via PI3K/Akt/mTORC1 Pathway

• DOI: 10.3389/fphar.2022.840521
• Publication Date: 2022-03-28T22:37:51Z
• Authors: Xiangyu Lu; Junkai Yao; Changxiang Li; Lingwen Cui; Yizhou Liu; Xiangning Liu; Gang Wang; Jianteng Dong; Qiong Deng; Yueyao Hu; Dongqing Guo; Wei Wang; Chun Li
• Keywords: Macrophage polarization

Background: Accumulating evidence suggests that coronary microvascular dysfunction (CMD) is one of the important causes artery diseases. Angiogenesis can effectively improve CMD by increasing blood supply capacity, recovering cardiac function and poor hemodynamics. Clinical studies have approved Shexiang Tongxin dropping pill (STDP), which has exerted remarkable roles on ameliorating CMD, but effects mechanisms STDPs angiogenesis not been clarified. Purpose: The purpose this study was to elucidate potential macrophage polarization-induced against CMD. Methods: Echocardiography, optical microangiography (OMAG), histological examination were applied evaluate cardioprotection proangiogenic left anterior descending (LAD) ligation-induced rats. In vitro, oxygen-glucose deprivation-reperfusion (OGD/R)-induced HUVEC model LPS-stimulated bone marrow-derived (BMDM) established observe M2 polarization. Results: improved function, increased density, number macrophages in heart accelerated proliferation, migration, tube formation OGD/R-induced HUVECs similar VEGF-A. Furthermore, BMDMs model, modulated polarization VEGF-A release via PI3K/AKT/mTORC1 pathway. Conclusion: promoted PI3K/Akt/mTORC1 Our results demonstrated phenotype transformation stimulating secretion may be as novel cardioprotective targets for treatment