Global trends in research on miRNA–microbiome interaction from 2011 to 2021: A bibliometric analysis

• DOI: 10.3389/fphar.2022.974741
• Publication Date: 2022-08-30T05:55:19Z
• Authors: Xiang-Yun Yan; Jun-Peng Yao; Yan-Qiu Li; Wei Zhang; Meng-Han Xi; Min Chen; Ying Li
• Keywords: Web of science

An increasing number of research suggests that the microRNA (miRNA)–microbiome interaction plays an essential role in host health and diseases. This bibliometric analysis aimed to identify status global scientific output, hotspots, frontiers regarding study miRNA–microbiome over past decade. We retrieved miRNA–microbiome-related studies published from 2011 2021 Web Science Core Collection database; R package bibliometrix was used analyze indicators, VOSviewer visualize field status, trends interplay. In total, 590 articles reviews were collected. A visual results showed significant increase publications time. China produced most papers, United States contributed highest citations. Shanghai Jiaotong University California Davis active institutions field. Most areas biochemistry molecular biology. Yu Aiming prolific writer, as indicated by h-index m-index, Liu Shirong commonly co-cited author. paper International Journal Molecular Sciences 2017 had The keywords “expression” “gut microbiota” appeared frequently, top three groups diseases among cancer (colorectal, et al.), inflammatory bowel disease (Crohn’s ulcerative colitis), neurological disorders (anxiety, Parkinson’s disease, al.). revealed have focused on miRNAs (e.g., miR-21, miR-155, miR-146a), gut microbes Escherichia coli , Bifidobacterium Fusobacterium nucleatum ), bacteria metabolites butyric acid), which potential improve diagnosis, treatment, prognosis found therapeutic strategies targeting axis focus miRNA drugs vitro ; however, some suggest vivo fermentation can greatly stability reduce degradation miRNA. Therefore, this method is worthy further research.