Modulation of the vitamin D receptor by traditional Chinese medicines and bioactive compounds: potential therapeutic applications in VDR-dependent diseases

• DOI: 10.3389/fphar.2024.1298181
• Publication Date: 2024-01-22T04:45:30Z
• Authors: Minghe Yao; Patrick Kwabena O...; Ayomide M. Akintibu; Haifeng Yan
• Keywords: Underpinning

The Vitamin D receptor (VDR) is a crucial nuclear that plays vital role in various physiological functions. To larger extent, the genomic effects of VDR maintain general wellbeing, and its modulation holds implications for multiple diseases. Current evidence regarding using vitamin or synthetic analogs to treat non-communicable diseases insufficient, though observational studies suggest potential benefits. Traditional Chinese medicines (TCMs) bioactive compounds derived from natural sources have garnered increasing attention. Interestingly, TCM formulae TCM-derived shown promise modulating activities. This review explores intriguing activity. We first emphasize latest information on genetic expression, function, structure VDR, providing comprehensive understanding this receptor. Following this, we several herbs known influence alongside mechanisms underpinning their action. Similarly, also discuss TCM-based target offering insights into roles modes