A rapid and simple non-radioactive assay for measuring uptake by solute carrier transporters

• DOI: 10.3389/fphar.2024.1355507
• Publication Date: 2024-04-24T04:34:35Z
• Authors: Kunling Song; Longbin Zhang; Xian Fu; Linfeng Li; Gaolin Zhu; Mingjun Wu; Wei Zhang; Jia He; Sanyong Zhu; Yongjun Dang; Jun-Yan Liu; Chang Chen; Zufeng Guo
• Keywords: Solute carrier family

Solute carrier (SLC) transport proteins play a crucial role in maintaining cellular nutrient and metabolite homeostasis are implicated various human diseases, making them potential targets for therapeutic interventions. However, the study of SLCs has been limited due to lack suitable tools, particularly cell-based substrate uptake assays, necessary understanding their biological functions drug discovery purposes.