Pharmacogenetic landscape of pain management variants among Mediterranean populations

• DOI: 10.3389/fphar.2024.1380613
• Publication Date: 2024-05-15T08:04:29Z
• Authors: Haifa Jmel; Wided Boukhalfa; Ismail Gouiza; Roua Ouled Seghaier; Hamza Dallali; Rym Kefi
• Keywords: Pharmacology; 0301 basic medicine; 03 medical and health sciences; Mediterranean populations; adverse drug reaction; pharmacogenes; opioids; admixture; Therapeutics. Pharmacology; RM1-950

Chronic pain is a major socioeconomic burden in the Mediterranean region. However, we noticed an under-representation of these populations pharmacogenetics management studies. In this context, aimed 1) to decipher pharmacogenetic variant landscape among compared worldwide order identify therapeutic biomarkers for personalized and 2) better understand biological process through