Clinical efficacy of Osteoking in knee osteoarthritis therapy: a prospective, multicenter, non-randomized controlled study in China

• DOI: 10.3389/fphar.2024.1381936
• Publication Date: 2024-06-28T04:48:35Z
• Authors: Jun Zhou; Zelu Zheng; Yuxin Luo; Yawei Dong; Yan Yan; Yi Zhang; Kaiqiang Tang; Rui Quan; Jiaming Lin; Kuayue Zhang; Pengxuan Dong; Rongtian Wang; Haijun He; Na Lin; Xisheng Weng; Baohong Mi; Yanqiong Zhang; Weiheng Chen
• Keywords: WOMAC

Background Osteoking has been extensively used for the treatment of knee osteoarthritis (KOA). However, it is lack high-quality evidence on clinical efficacy against KOA and comparison with that nonsteroidal anti-inflammatory drugs (NSAIDs). Aims To evaluate safety in treating KOA. Methods In current study, a total 501 subjects were recruited from 20 medical centers, divided into group ( n = 428) NSAIDs 73). The Propensity Score Matching method was to balance baseline data different groups. Then, therapeutic effects evaluated using VAS score, WOMAC EQ-5D-3L EQ-VAS, while two both assessed based dry mouth, dizziness, diarrhea, etc. Results After 8 weeks treatment, compared group, score [2.00 (1.00, 3.00) vs. 3.00 (2.00, 4.00)], pain [10.00 (8.00, 13.00) 11.00 16.00) ], physical function [32.00 (23.00, 39.00) 39.07 ± 16.45], [44.00 (31.00, 55.00) 53.31 22.47) [0.91 (0.73, 0.91) 0.73 (0.63, 0.83) ] EQ-VAS [80.00 (79.00, 90.00) 80.00 (70.00, 84.00) improved by more effectively than NSAIDs. Osteoking, scores patients reduced 6.00 (5.00, 7.00) 2.00 p < 0.05), which better those starting 2 during this observation. Importantly, further subgroup analysis revealed suitable alleviating various symptoms over 65 years old, female, KL II-III grade 4-7 scores, under old 8–10 scores. Of note, there no differences adverse events reactions between groups drugs. Conclusion may exert satisfying relieving joint improving life quality without any reactions, especially grades 4–7 Clinical Trial Registration: https://www.chictr.org.cn/showproj.html?proj=55387 , Identifier ChiCTR2000034475