Oscillations Governed by the Incoherent Dynamics in Necroptotic Signaling

• DOI: 10.3389/fphy.2021.726638
• Publication Date: 2021-08-19T14:27:20Z
• Authors: Fei Xu; Zhiyong Yin; Ligang Zhu; Jun Jin; Qingzhu He; Xiang Li; Jianwei Shuai
• Keywords: Oscillation (cell signaling); Robustness; Positive feedback

Emerging evidences have suggested that oscillation is important for the induction of cell death. However, whether and how behavior involved required necroptosis remain elusive. To address this question, a minimal necroptotic circuit proposed based on CNS pathway. Stochastic parameter analysis demonstrates essential structure constituted by paradoxical component embedded with positive feedback among three protein nodes, i.e., RIP1, caspase-8, RIP3. Distribution characteristics all parameters in stable are investigated as well, unidirectional bias fast slow dynamics high occurrence probability identified. Four types behaviors classified their robustness further explored, implying more robust than behavior. In addition, bifurcation landscape approach employed to study stochastic global stability oscillations, revealing possible switching strategies different behaviors. Taken together, our provides natural physical bases understanding oscillations network, advancing knowledge regulating various death signaling.