Computational Modeling of Interacting VEGF and Soluble VEGF Receptor Concentration Gradients

• DOI: 10.3389/fphys.2011.00062
• Publication Date: 2011-10-04T04:38:14Z
• Authors: Yasmin L. Hashambhoy; John C. Chappell; Shayn M. Peirce-C...; Victoria L. Bautch; Feilim Mac Gabhann
• Keywords: Sprouting angiogenesis

Experimental data indicates that soluble vascular endothelial growth factor (VEGF) receptor 1 (sFlt-1) modulates the guidance cues provided to sprouting blood vessels by VEGF-A. To better delineate role of sFlt-1 in VEGF signaling, we have developed an experimentally based computational model. This model describes dynamic spatial transport VEGF, and its binding receptors Flt-1 Flk-1, a mouse embryonic stem cell vessel morphogenesis. The represents local environment single vessel. Our simulations predict secretion increased sequestration results decreased VEGF-Flk-1 levels on sprout surface. In addition, predicts increases relative gradient along surface, which could alter perception directionality cues. We also show proximity neighboring sprouts may gradients, binding, growth. As distances decrease, probability will move divergent directions increases. is useful tool for determining how gradients contribute distribution can be used conjunction with experimental explore multi-cellular interactions relationships between drive angiogenesis.