Morning Bright Light Treatment for Sleep-Wake Disturbances in Primary Biliary Cholangitis: A Pilot Study

• DOI: 10.3389/fphys.2018.01530
• Publication Date: 2018-11-05T04:15:28Z
• Authors: Matteo Turco; Nora Cazzagon; Irene Franceschet; Chiara Formentin; Giovanni Frighetto; Francesca Giordani; Nicola Cellini; Gabriella Mazzotta; Rodolfo Costa; Benita Middleton; Debra J. Skene; Annarosa Floreani; Sara Montagnese
• Keywords: Sleep

Patients with Primary Biliary Cholangitis (PBC) exhibit delayed sleep-wake habits, disturbed night sleep and daytime sleepiness/fatigue. Such combination of symptoms is reminiscent phase disorder (DSPD), which benefits from morning light treatment. The aim the present pilot study was to test effect treatment in a group 13 well-characterized patients PBC [all females; (mean ± SD) 53±10 yrs]. Six healthy individuals (4 females, 57±14 yrs) 7 cirrhosis (1 female, 57±12 served as controls disease controls, respectively. At baseline, all participants underwent an assessment quality life, diurnal preference, quality/timing (subjective plus actigraphy), sleepiness, urinary 6-sulphatoxymelatonin (aMT6s) rhythmicity. Then they 15-day course bright treatment, immediately after getting up (light box, 10000 lux, 45 mins) whilst monitoring patterns aMT6s both had significantly worse subjective compared controls. In PBC, resulted improvement reduction sleepiness. addition, their onset get-up time were advanced. Finally, robustness rhythmicity (i.e. strength cosinor fit) increased administration but post hoc comparisons not significant any groups. conclusion, brief positive effects on quality, sleepiness timing PBC. This unobtrusive, side-effect free, non-pharmacological worthy further study.