Comprehensive Analysis of Macrocirculation and Microcirculation in Microgravity During Parabolic Flights

• DOI: 10.3389/fphys.2020.00960
• Publication Date: 2020-08-13T04:39:31Z
• Authors: Nana-Yaw Bimpong-...; Johanna M. Muessig; Thorben Knost; Maryna Masyuk; Stephan Binneboessel; Amir M. Nia; Malte Kelm; Christian Jung
• Keywords: Supine position; Weightlessness; Hypergravity; Interquartile range; Spaceflight

Profound knowledge about cardiovascular physiology in the setting of microgravity can help course preparations for human space missions. So far, influences on system have been demonstrated, particularly pertaining to venous fluid shifts. Yet, little is known mechanisms these adaptations continuous macrocirculatory level and regarding microcirculation.Twelve healthy volunteers were subjected alternating hypergravity parabolic flight maneuvers. Under conditions, as well normal gravity, sublingual microcirculation was assessed by intravital sidestream dark field microscopy. Furthermore, hemodynamic parameters such heart rate, blood pressure, cardiac output recorded beat-to-beat analysis. In settings, data acquisition performed seated supine postures.Systolic [median 116 mmHg (102; 129) interquartile range (IQR) vs. 125 (109; 136) IQR, p = 0.01] diastolic 72 (61; 79) IQR 80 (69; 89) 0.003] pressure reduced, 6.9 l/min (6.5; 8.8) 6.8 (6.2; 8.5) 0.0002] increased weightlessness compared gravitation phases but not posture. However, represented perfused proportion vessels total vessel density unaffected acute weightlessness.Profound changes macrocirculation found postures, postures. remained stable all