Supplementation of Lipoic Acid, Zinc and Clopidogrel Reduces Mortality Rate and Incidence of Ventricular Arrhythmia in Experimental Myocardial Infarction

• DOI: 10.3389/fphys.2021.582223
• Publication Date: 2021-03-17T04:47:15Z
• Authors: Enas Abdel-Hady; Fatma Mohamed; Mona Ahmed; Mohamed Abdel-Salam; Mahmoud Ayobe
• Keywords: Creatine kinase; Creatine

Despite the significant advances in management of coronary heart diseases, myocardial infarction (MI) is still associated with a high mortality rate. The present study was planned to investigate possible protective effects anti-oxidants lipoic acid and zinc sulfate as well anti-platelet clopidogrel on cardiac dysfunction experimental isoproterenol (ISO)-induced MI, aiming at achieving useful means for protection therapy against MI. Wistar rats both sexes were allocated into five groups: control, untreated MI pre-treated acid, zinc, or clopidogrel. All subjected ECG recording measurement plasma levels troponin I, creatine kinase-MB (CK-MB) unit, triglycerides total cholesterol. hearts isolated studied Langendorff preparation assessment intrinsic activities. results revealed that percent markedly reduced upon pre-treatment arrhythmia also decreased except rats. ST-segment elevation significantly CK-MB only variable hypolipidemic effect. Hearts showed augmented inotropic activity basal response β-adrenergic stimulation. While improved rate contraction increased flow Overall, these indicate variably effective modifying ISO-induced insults offered partial damage.