Serum Glycerophospholipid Profile in Acute Exacerbation of Chronic Obstructive Pulmonary Disease

• DOI: 10.3389/fphys.2021.646010
• Publication Date: 2021-02-15T04:21:29Z
• Authors: Xiaoyan Gai; Chenglin Guo; Linlin Zhang; Lijiao Zhang; Mairipaiti Abulikemu; Juan Wang; Qingtao Zhou; Yahong Chen; Yongchang Sun; Chun Chang
• Keywords: Glycerophospholipids

Studies have shown that glycerophospholipids are involved in the pathogenesis of chronic obstructive pulmonary disease (COPD). This study adopted targeted metabolomic analysis to investigate changes serum acute exacerbation (AECOPD) and their differential expression patients with different inflammatory subtypes. Patients AECOPD admitted between January 2015 December 2017 were enrolled, clinical data collected. The patients’ gender, age, body mass index, lung function recorded. Routine blood induced sputum tests performed. Liquid chromatography-mass spectrometry was used detect glycerophospholipid metabolic profiles analyze profile recovery stages as well differences A total 58 hospitalized for AECOPD, including 49 male a mean age 74.8 ± 10.0 years. In profiles, lysophosphatidylcholine (LPC) 18:3, lysophosphatidylethanolamine (LPE) 16:1, phosphatidylinositol (PI) 32:1 significantly reduced stage compared ( P < 0.05). three plot receiver operating characteristic curves predict exacerbation/recovery stage, areas under all above 70%. There no metabolites two groups eosinophil percentage (EOS%) ≥2% <2% at exacerbation. LPC LPE PI subtype EOS Abnormalities metabolism may be onset especially non-eosinophilic subtype.