Mechanical Principles Governing the Shapes of Dendritic Spines

• DOI: 10.3389/fphys.2021.657074
• Publication Date: 2021-06-16T07:15:03Z
• Authors: Haleh Alimohamadi; Miriam K. Bell; Shelley Halpain; Padmini Rangamani
• Keywords: Dendritic filopodia; Filopodia

Dendritic spines are small, bulbous protrusions along the dendrites of neurons and sites excitatory postsynaptic activity. The morphology has been implicated in their function synaptic plasticity shapes have well-characterized, but potential mechanics underlying shape development maintenance not yet fully understood. In this work, we explore mechanical principles that could underlie specific using a minimal biophysical model membrane-actin interactions. Using model, first identify possible force regimes give rise to classic spine shapes—stubby, filopodia, thin, mushroom-shaped spines. We also use investigate how neck might be stabilized periodic rings actin or associated proteins. Finally, predict cooperation between generation ring structures can regulate energy landscape across wide range tensions. Thus, our study provides insights into aspects actin-mediated tension play critical roles maintenance.