Dietary ferulic acid supplementation improved cottonseed meal-based diet utilization by enhancing intestinal physical barrier function and liver antioxidant capacity in grass carp (Ctenopharyngodon Idellus)

• DOI: 10.3389/fphys.2022.922037
• Publication Date: 2022-08-22T04:42:30Z
• Authors: Shiyou Chen; Yan Lin; Hequn Shi; Linghong Miao; Bo Liu; Xianping Ge
• Keywords: Grass carp; Cottonseed meal

The present study explored the effects of ferulic acid (FA) supplementation in cottonseed meal (CSM)-based diets on grass carp growth performance, feed utilization, liver antioxidation status, and intestinal physical barrier function. Here, four experimental supplemented with FA at graded levels (0, 50, 100 200 mg/kg) CSM as main protein source (384.6 g/kg feed) for an 8-week feeding trial. Our results indicated that mg/kg a CSM-based diet significantly improved performance [including final body weight (FBW), gain rate, specific rate] utilization conversion ratio efficiency ratio] (p < 0.05). polynomial regression analysis based FBW recommended optimal dose was 204 mg/kg. Compared no supplementation, reduced malondialdehyde increased glutathione reductase activities 0.05) total superoxide dismutase blood alanine transaminase control group, also led to mRNA expression zo-1, zo-2, occludin, claudin-b, claudin-3, claudin-7a, claudin-12, encoding tight junction proteins Notably, could reduce lipid deposition by regulating bile (BA) secretion. In this study, BA levels, respectively 0.05); activated expressions fxr cyp7a1 Furthermore, whole-body composition presented treatment relieved deposition, particularly 50 Moreover, triglyceride cholesterol were lower high-density lipoprotein higher than Taken together, may be beneficial additive boost fish increase utilization.