Comparison of cardiac image-derived input functions for quantitative whole body [18F]FDG imaging with arterial blood sampling

• DOI: 10.3389/fphys.2023.1074052
• Publication Date: 2023-03-22T05:02:36Z
• Authors: Murray Bruce Reed; Godber Mathis God...; Chrysoula Vraka; Ivo Rausch; Magdalena Ponce d...; Valentin Popper; Barbara Geist; Lukas Nics; Arkadiusz Komorowski; Georgios Karanikas; Thomas Beyer; Tatjana Traub-Wei...; Andreas Hahn; Werner Langsteger; Marcus Hacker; Rupert Lanzenberger
• Keywords: Blood sampling; Gold standard (test); Arterial blood

Introduction: Dynamic positron emission tomography (PET) and the application of kinetic models can provide important quantitative information based on its temporal information. This however requires arterial blood sampling, which be challenging to acquire. Nowadays, state-of-the-art PET/CT systems offer fully automated, whole-body (WB) modelling protocols using image-derived input functions (IDIF) replace sampling. Here, we compared validity an automatic WB model protocol reference standard function (AIF) for both clinical research settings. Methods: Sixteen healthy participants underwent dynamic [ 18 F]FDG scans a continuous bed motion system with simultaneous Multiple processing pipelines that included manually generated IDIFs derived from aorta left ventricle, without correction were AIF. Subsequently images glucose metabolism evaluate performance different functions. Results: We observed moderate high correlations between AIF regarding area under curve (r = 0.49–0.89) as well cerebral metabolic rate (CMRGlu) 0.68–0.95). Manual placing further improved their similarity Discussion: In general, vendor is feasible approach quantification CMRGlu both, settings where expertise or time not available. However, advise rigorous inspection placement volume interest, resulting IDIF, values ensure valid interpretations. requiring longer scan times cohorts are prone involuntary movement, manual IDIF definition additional recommended, this has greater accuracy reliability.