Hibiscus attenuates renovascular hypertension–induced aortic remodeling dose dependently: the oxidative stress role and Ang II/cyclophilin A/ERK1/2 signaling

• DOI: 10.3389/fphys.2023.1116705
• Publication Date: 2023-06-21T09:40:33Z
• Authors: Asmaa Mohammed Sh...; Ahmed Fawzy; Hend Ashour; Marwa Abdel-Rahman; Hend Elsayed Nasr; Lina Abdelhady Mo...; Noha Samir Abdel ...; Amr M. Mahrous; Shereen Abdelfattah
• Keywords: Cypa; Hibiscus Sabdariffa; Renovascular Hypertension

Introduction: The high levels of angiotensin II (Ang II) can modify the vascular tone, enhance smooth muscle cells (VSMCs) proliferation and hypertrophy increase inflammatory cellular infiltration into vessel wall. old herbal nonpharmacological agent, Hibiscus (HS) sabdariffa L has multiple cardioprotective impacts; thus, we investigated role HS extract in amelioration renovascular hypertension (RVH)-induced aortic remodeling. Materials methods: Thirty-five rats (7/group) were randomly allocated 5 groups; group: I: Control-sham group, RVH II, III, IV, V. groups subjected to modified Goldblatt two-kidneys, one clip (2K1C) for induction hypertension. In left untreated whereas group V: RVH-rats treated 6 weeks with low dose hibiscus (LDH), medium (MDH), (HDH) respectively. Results: We found that augmented pro-contractile response rings was ameliorated secondary in-vivo treatment dependently. cyclophilin A (CyPA) protein positively correlated adhesion molecule-1 (VCAM-1) ERK1/2, which, turn, contribute reactive oxygen species (ROS) production. Daily intake renovation by enhancing antioxidant capacity, restraining fibrosis, downregulation metastasis associated lung adenocarcinoma transcript (MALAT1), (CyPA)/ERK1/2 levels. Discussion: Adding beneficial effects, aqueous able inhibit cell induced 2K1C model. Thus, adding more privilege utilization traditional extracts attenuate RVH-induced aortopathy.