Effects of voluntary running on the skeletal muscle of rats with pulmonary artery hypertension

• DOI: 10.3389/fphys.2023.1206484
• Publication Date: 2023-07-04T12:40:12Z
• Authors: Filipe Rios Drummond; Leôncio Lopes Soares; Tiago Ferreira Leal; Luciano Bernardes...; Leonardo Mateus T...; Meilene Ribeiro F...; Victor Neiva Lavo...; Denise Coutinho M...; Miguel Araújo Car...; Mariana Machado N...; Luciane Carla Alb...; Emily Correna Car...; Clovis Andrade Neves; Antônio José Natali
• Keywords: Turnover; Exertion

The effects of voluntary running on the skeletal muscle rats with pulmonary arterial hypertension (PAH) were tested in present study. PAH was induced by a single injection monocrotaline (MCT, 60 mg/kg). Rats sedentary (HS) group had their tolerance to physical exertion reduced throughout experiment, while those control (SC), exercise (EC), (EH) and median (EM) groups maintained or increased. Despite that, muscular citrate synthase activity not different between groups. survival time higher EH (32 days) than SH (28 ( p = 0.0032). showed lower percentage fiber extracellular matrix compared < 0.0001). However, EM presented Regarding gene expression, expression PGC1-α 0.0024) VEGF 0.0033) SC, elevated EH. No difference found for carbonylated protein levels > 0.05), TNF-α/IL-10 ratio augmented 0.0277). In conclusion, augments proportion affects inflammatory mitochondrial biogenesis’ markers MCT-induced PAH, which benefits effort.