Complex Networks of Prion-Like Proteins Reveal Cross Talk Between Stress and Memory Pathways in Plants

• DOI: 10.3389/fpls.2021.707286
• Publication Date: 2021-07-26T13:25:27Z
• Authors: Sampurna Garai; Citu; Sneh L. Singla-Pa...; Sudhir K. Sopory; Charanpreet Kaur; Gitanjali Yadav
• Keywords: Interactome; Transgenerational epigenetics; Retrotransposon

Prions are often considered as molecular memory devices, generating reproducible of a conformational change. Prion-like proteins (PrLPs) have been widely demonstrated to be present in plants, but their role plant stress and remains unexplored. In this work, we report the widespread presence PrLPs plants through comprehensive meta-analysis 39 genomes representing major taxonomic groups. We find diverse functional roles associated with these various species term full complement genome its “ prionome.” particular, found rice prionome being significantly enriched transposons/retrotransposons (Ts/RTRs) identified over 60 that were differentially regulated developmental responses. This prompted us explore whether what extent may build memory. By integrating available interactome, transcriptome, regulome data sets, could links between pathways would not otherwise discernible. Regulatory inferences derived from superimposition sets revealed complex network cross talk PrLPs, transcription factors (TFs), genes involved priming. integrative connects transient transgenerational mechanisms suggesting rely upon protein-based signals addition chromatin-based epigenetic signals. Taken together, our work provides important insights into anticipated prion-like candidates memory, paving way for more focused studies validating acclimation.