Home-based transcranial direct current stimulation in mild neurocognitive disorder due to possible Alzheimer’s disease. A randomised, single-blind, controlled-placebo study

• DOI: 10.3389/fpsyg.2022.1071737
• Publication Date: 2023-01-03T14:40:05Z
• Authors: Encarnacion Satorres; Joaquin Escudero ...; Elena Real; Alfonso Pitarque; Iraida Delhom; Juan C. Melendez
• Keywords: Transcranial Direct Current Stimulation; Neurocognitive; Cognitive Training; Dorsolateral prefrontal cortex

Mild neurocognitive disorder (mNCD), a pre-dementia stage close to Cognitive Impairment, shows progressive and constant decline in the memory domain. Of non-pharmacological therapeutic interventions that may help decelerate neurodegenerative progress, transcranial direct current stimulation (tDCS) beneficial effects on learning curve, immediate recall, verbal executive functions. The purpose of this research was study effect tDCS general cognition, delayed functions by comparing an active group with placebo mNCD patients.Participants were 33 due possible AD, randomly assigned two groups: 17 16 tDCS. Ten sessions conducted over left dorsolateral prefrontal cortex. Several neuropsychological scales administered assess primary outcome measures cognitive function, ability, whereas secondary included function tests. All participants evaluated at baseline end intervention. Mixed ANOVAs performed.Significant obtained increases scores group. However, there no significant performance.The present demonstrated effectiveness group, compared improving cognition memory, as previous studies found. Taken together, our data suggest is simple, painless, reproducible easy technique useful for treating alterations found diseases.