Health-related quality of life in severe hypersensitivity reactions: focus on severe allergic asthma and hymenoptera venom anaphylaxis—a cross-sectional study

• DOI: 10.3389/fpsyg.2024.1394954
• Publication Date: 2024-08-23T04:59:04Z
• Authors: Luisa Ricciardi; Orlando Silvestro; Gabriella Martino; Antonino Catalano; Carmelo Mario Vic...; Trine Lund-Jacobsen; Peter Schwarz; Daniela Sapienza; Sebastiano Gangemi; Giovanni Pioggia; Concetto Mario Gi...
• Keywords: immunology; hymenoptera venom anaphylaxis; 03 medical and health sciences; 0302 clinical medicine; H-R quality of life; Psychology; severe allergic asthma; clinical psychology; alexithymia; H-R quality of life, alexithymia, clinical psychology, hymenoptera venom anaphylaxis, immunology, outdoor workers, severe allergic asthma, severe hypersensitivity reactions; BF1-990

BackgroundGrowing evidence reveals the important role of clinical psychological factors in chronic-immune diseases. The aim of this study was to investigate Health-Related Quality of Life (HR-QoL), depression, anxiety, and alexithymia in patients with severe hypersensitivity reactions such as Severe Allergic Asthma (SAA) and Hymenoptera Venom Anaphylaxis (HVA).MethodsThe Short-Form Health Survey-36 (SF-36), the Beck Depression Inventory Questionnaire (BDI-II), the Hamilton Anxiety Rating Scale (HAM-A) and the Toronto Alexithymia Scale (TAS-20) were used to assess HR-QoL and clinical psychological features of patients with SAA and HVA.ResultsOverall, 78 patients were recruited. Patients with SAA (n = 35) reported lower scores for physical functioning [65 (58–75) vs. 90 (85–95); p = <0.001], role limitations due to physical health [25 (0–50) vs. 62 (50–75); p = 0.004], bodily pain [47.5 (41.1–61.3) vs. 55.5 (55–96); p = 0.001], general health [40 (30–60) vs. 70 (50–80); p = 0.0003] and social functioning [50 (37.5–62.5) vs. 62.5 (54.9–75); p = 0.007] while higher scores for depressive symptoms [14 (11–15.4) vs. (9.5 (6–15.4); p = 0.05)] compared to HVA patients (n = 43). All the dimensions of SF-36 were negatively correlated with anxiety (r from −0.26 to −0.66; pall < 0.01) and depressive symptoms (r from −0.44 to −0.73; pall < 0.001). Alexithymia was negatively correlated with vitality (r = −0.28; p = 0.02) and mental health (r = −027; p = 0.03). Additionally, patients with alexithymia (38% of participants) showed higher levels of depressive symptoms [9.5 (10–19) vs. 14 (6–13.9); p = 0.005] and anxiety levels [31 (27.9–35) vs. 24 (16–33.9); p = 0.02]; they also showed less vitality [40 (39.9–50) vs. 55 (50–60) p = 0.01], social functioning [50 (37.5–62.5) vs. 62.5 (50 vs. 75); p = 0.01] and mental health [48 (44–60) vs. 68 (56–76); p = 0.004].ConclusionClinical psychological features due to severe hypersensitive reactions may contribute to the patient’s perceived HR-QoL. Focused clinical psychological interventions should be promoted to improve the clinical management of such conditions.