Plasma Metabolomics Profiling of Metabolic Pathways Affected by Major Depressive Disorder

• DOI: 10.3389/fpsyt.2021.644555
• Publication Date: 2021-09-27T14:32:13Z
• Authors: Yue Du; Jinxue Wei; Zijian Zhang; Xiao Yang; Min Wang; Yu Wang; Xiongwei Qi; Liansheng Zhao; Yang Tian; Wanjun Guo; Qiang Wang; Wei Deng; Minli Li; Dongtao Lin; Tao Li; Xiaohong Ma
• Keywords: Metabolic pathway

Background: Major depressive disorder (MDD) is a common disease which complicated by metabolic disorder. Although MDD has been studied relatively intensively, its metabolism yet to be elucidated. Methods: To profile the global pathophysiological processes of patients, we used metabolomics identify differential metabolites and applied new database Metabolite set enrichment analysis (MSEA) discover dysfunctions pathways this disease. Hydrophilic were profiling plasma from 55 patients 100 sex-, gender-, BMI-matched healthy controls. The then analyzed in MSEA an attempt different pathways. investigate dysregulated pathways, further divided into two cohorts: (1) with anxiety symptoms (2) without symptoms. Results: Metabolites hit those correlated Altogether, 17 enriched 23 Three anxiety, including glycine serine metabolism, arginine proline phenylalanine tyrosine metabolism. In addition, L-glutamic acid was positively severity depression retardation if Conclusions: Different kinds found patients. Disorder observed both without.