Moderators of ayahuasca’s biological antidepressant action

• DOI: 10.3389/fpsyt.2022.1033816
• Publication Date: 2022-12-05T05:13:31Z
• Authors: Geovan Menezes de...; Vagner Deuel de O...; Ana Cecília de Me...; Raíssa Nóbrega de...; Fernanda Palhano-...; Bruno Lobão-Soares; Fúlvio Aurélio de...; Emerson Arcoverde...; João Paulo Maia-d...; Daniel Perkins; Jerome Sarris; Dráulio Barros de...; Nicole Leite Galv...
• Keywords: Ayahuasca

The understanding of biological responses to psychedelics with antidepressant potential is imperative. Here we report how a set acute parameters, namely emotional (depressive symptoms), cognitive (psychedelic experience), and physiological (salivary cortisol), recorded during an ayahuasca dosing session, modulated serum brain-derived neurotrophic factor (BDNF), cortisol (SC), interleukin 6 (IL-6), plasma C-reactive protein (CRP), salivary awakening response (CAR).