Repetitive transcranial magnetic stimulation combined with cognitive behavioral therapy treatment in alcohol-dependent patients: A randomized, double-blind sham-controlled multicenter clinical trial

• DOI: 10.3389/fpsyt.2022.935491
• Publication Date: 2022-10-04T07:03:25Z
• Authors: Xiaorui Hu; Tian Zhang; Hongkun Ma; Xuhui Zhou; Hongxuan Wang; Xiaohong Wang; Chang Cheng; Yanfei Li; Ranran Duan; Bo Zhang; Huaizhi Wang; Jia Lu; Chuanyi Kang; Na Zhao; Yingjie Zhang; Lu Tian; Jun Liu; Jingjing Shi; Zhe Wang; Xinxin Zhou; Shuang Zhu; Qingxia Liu; Xuemin Li; Honghui Wang; Mingxuan Nie; Mei Yang; Jianzhong Yang; Yong Chi; Xiaofeng Zhu; Jian Hu; Yanjie Jia; Ying Peng; Lei Liu
• Keywords: Brain stimulation; Transcranial Direct Current Stimulation

Alcohol dependence (AD) is a complex addictive disorder with high relapse rate. Previous studies have shown that both repetitive transcranial magnetic stimulation (rTMS) and cognitive behavioral therapy (CBT) may be effective for AD, we aim to explore more treatment options reduce rates AD.A total of 263 AD patients were recruited. They divided into six groups according the location type rTMS: left dorsolateral prefrontal cortex (DLPFC), right DLPFC, sham stimulation, whether they received CBT treatment: fixed schedule (C1) without plan (C0). There included in rTMS + C0 group (n = 50), C1 37), 45), 42), 49), 40). We used obsessive compulsive drinking scale (OCDS), visual analogue (VAS), alcohol (ADS), montreal assessment (MoCA), generalized anxiety disorder-7 (GAD-7), patient health questionnaire-9 items (PHQ-9), Pittsburgh sleep quality index (PSQI) assess cravings, dependence, cognition, anxiety, depression, quality. followed up evaluated relapse.The rate was significantly higher than (P 0.006), 0.031), 0.043). The showed compared 0.046). no significant difference between other groups. repeated-measures ANOVA an interaction effect time (PHQ-9) reduction 0.020). Logistic analysis indicated smoking consumption independent determinants < 0.05). At 24 weeks follow-up, Kaplan-Meier survival reveal there statistically 0.025), has best dependent patients. Cox regression confirmed current smoking, cholesterol, bilirubin (TBIL) level risk factors 0.05).This study first suggest combination potentially reducing relapse.