The interaction between the major vault protein rs4788186 polymorphism, alcohol dependence, and depression among male Chinese problem drinkers

• DOI: 10.3389/fpsyt.2023.1111712
• Publication Date: 2023-07-21T20:53:05Z
• Authors: Yuyu Wu; Ke Zhao; Yingjie Chen; Liujun Wu; Feng Qiu; Yuying Yuan; Guanghui Shen; Kexin Wang; Yimin Kang; Yongsheng Jiang; Wei Wang; Li Chen; Yanlong Liu; Xuebo Pan; Fan Wang; Longteng Xie
• Keywords: Depression; Alcohol Dependence

Objective Alcohol use disorder (AUD) is the second most prevalent mental and might be related to depression. Major vault protein (MVP) a cytoplasmic vesicle transport. The present study aimed investigate interaction between genetic variant (MVP rs4788186) depression in adult male Han Chinese with AUD during withdrawal. Methods All participants ( N = 435) were diagnosed AUD. dependence level was measured using Michigan Alcoholism Screening Test, self-rating scale. Genomic DNA extracted from peripheral blood genotyped. Results Hierarchical regression analysis identified an MVP rs4788186 alcohol for β −0.17, p < 0.05). Then, region of significance test performed interpret effect. Re-parameterized models revealed that problem severity fit strong differential susceptibility model R 2 0.08, 0.001), suggesting AA homozygotes would more likely subjects G allele experience major symptoms. Conclusion Carriers homozygote may susceptible severe problems higher levels