Utilizing portable electroencephalography to screen for pathology of Alzheimer’s disease: a methodological advancement in diagnosis of neurodegenerative diseases

• DOI: 10.3389/fpsyt.2024.1392158
• Publication Date: 2024-05-24T10:52:21Z
• Authors: Masahiro Hata; Yuki Miyazaki; Kohji Mori; Kenji Yoshiyama; Shoshin Akamine; Hideki Kanemoto; Shiho Gotoh; Hisaki Omori; Atsuya Hirashima; Yuto Satake; Takashi Suehiro; Shun Takahashi; Manabu Ikeda
• Keywords: Brain disease

Background The current biomarker-supported diagnosis of Alzheimer’s disease (AD) is hindered by invasiveness and cost issues. This study aimed to address these challenges utilizing portable electroencephalography (EEG). We propose a novel, non-invasive, cost-effective method for identifying AD, using sample patients with biomarker-verified facilitate early accessible screening. Methods included 35 confirmed via cerebrospinal fluid sampling, age- sex-balanced healthy volunteers (HVs). All participants underwent EEG recordings, focusing on 2-minute resting-state epochs closed eyes state. recordings were transformed into scalogram images, which analyzed “vision Transformer(ViT),” cutting-edge deep learning model, differentiate from HVs. Results application ViT the images derived data demonstrated significant capability distinguish between AD achieved an accuracy 73%, area under receiver operating characteristic curve 0.80, indicating robust performance in pathology neurophysiological measures. Conclusions Our findings highlight potential combined advanced techniques as transformative tool screening AD. not only contributes understanding but also opens new avenues development non-invasive diagnostic methods. proposed approach paves way future clinical applications, offering promising solution limitations practices dementia.