The diagnostic utility of IL-10, IL-17, and PCT in patients with sepsis infection

• DOI: 10.3389/fpubh.2022.923457
• Publication Date: 2022-07-22T16:09:00Z
• Authors: Wei Zhang; Weiwei Wang; Weiwei Hou; Chenfei Jiang; Jingwen Hu; Li Sun; Liqing Hu; Jian Wu; Anquan Shang
• Keywords: Calcitonin; 0303 health sciences; Calcitonin Gene-Related Peptide; Interleukin-17; Interleukin-10; 3. Good health; sepsis; nomogram; IL-17; 03 medical and health sciences; Sepsis; IL-10; Humans; diagnostic value; Public Health; Public aspects of medicine; RA1-1270; Protein Precursors; PCT; Procalcitonin; Biomarkers

ObjectiveThe purpose of this study is to determine the diagnostic value and net clinical benefit of interleukin-10 (IL-10), interleukin-17 (IL-17), procalcitonin (PCT), and combination tests in patients with sepsis, which will serve as a standard for sepsis early detection.Patients and methodsAn investigation of 84 sepsis patients and 81 patients with local inflammatory diseases admitted to the ICU of Tongji University Hospital in 2021. In addition to comparing inter-group variability, indicators relevant to sepsis diagnosis and therapy were screened.ResultsLASSO regression was used to examine PCT, WBC, CRP, IL-10, IFN-, IL-12, and IL-17. Multivariate logistic regression linked IL-10, IL-17, and PCT to sepsis risk. The AUC values of IL-10, IL-17, PCT, and the combination of the three tests were much higher than those of standard laboratory infection indicators. The combined AUC was greater than the sum of IL-10, IL-17, and PCT (P < 0.05). A clinical decision curve analysis of IL-10, IL-17, PCT, and the three combined tests found that the three combined tests outperformed the individual tests in terms of total clinical benefit rate. To predict the risk of sepsis using IL-10, IL-17, and PCT had an AUC of 0.951, and the model's predicted probability was well matched. An examination of the nomogram model's clinical value demonstrated a considerable net therapeutic benefit between 3 and 87%.ConclusionThe IL-10, IL-17, and PCT tests all have a high diagnostic value for patients with sepsis, and the combination of the three tests outperforms the individual tests in terms of diagnostic performance, while the combined tests have a higher overall clinical benefit rate.