Hypervirulent carbapenem-resistant Klebsiella pneumoniae causing highly fatal meningitis in southeastern China

• DOI: 10.3389/fpubh.2022.991306
• Publication Date: 2022-10-17T15:11:53Z
• Authors: Na Huang; Huaiyu Jia; Beibei Zhou; Cui Zhou; Jianming Cao; Wenli Liao; Shixing Liu; Lingbo Wang; Liqiong Chen; Lijiang Chen; Tieli Zhou; Jianzhong Ye
• Keywords: Broth microdilution; Agar dilution; Multilocus sequence typing; Carbapenem

Klebsiella pneumoniae (K. pneumoniae) is one of the most common causes bacterial meningitis worldwide. The purpose this study was to investigate clinical and microbiological characteristics K. meningitis, as well association antimicrobial resistance, virulence, patient prognosis. data patients with from 2014 2020 in a tertiary teaching hospital were retrospectively evaluated. Antimicrobial susceptibility profiles performed by agar dilution method broth microdilution method. isolates detected for virulence-related genes, resistance capsular serotypes, molecular subtypes. A total 36 individuals included study, accounting 11.3% (36/318) all cases meningitis. Of available isolates, K1, K47, K64 tied frequent serotype (7/36, 19.4%). MLST analysis classified into 14 distinct STs, ST11 being (14/36, 38.9%). Carbapenem found 44.4% (16/36) while hypervirulent (HvKP) 66.7% (24/36) isolates. carbapenem-resistant (Hv-CRKP) then confirmed be 36.1% (13/36). Importantly, caused Hv-CRKP had statistically significant higher mortality than other (92.3%, 12/13 vs. 56.5%, 13/23; P < 0.05). high percentage fatality pneumoniae-caused particularly strains, should concern. More effective surveillance treatment solutions will required future avoid spread these life-threatening infections over world.