The relationship between urinary selenium levels and risk of gestational diabetes mellitus: A nested case–control study

• DOI: 10.3389/fpubh.2023.1145113
• Publication Date: 2023-03-27T05:06:01Z
• Authors: Yuanxia Liu; Hongmei Chen; Mengtian Zhang; Gangjiao Zhu; Yan Yang; Yuanyuan Li; Wei Lu; Hongling Zhang
• Keywords: Nested case-control study

Selenium (Se) is an essential trace element for the human body. Serum Se and urinary are also biomarkers to assess exposure status. However, studies focusing on association between risk of gestational diabetes mellitus (GDM) rare. To investigate GDM. A nested case-control study based a prospective birth cohort in Wuhan, China, which focuses effects prenatal environmental factors pregnant women children's health was conducted. Two hundred twenty-six cases 452 controls were included. Maternal urine samples collected before GDM diagnosis, levels determined. We assessed with by conditional logistic regression maternal level as categorical variable, estimated glucose multiple linear regression. The potential modifier roles age fetal sex have been assessed. Lower significantly associated higher (OR = 2.35 tertile 1, 95% CI:1.36-4.06; adjusted OR 1.79 2, 95%CI:1.09-2.95; p trend 0.01). Fetal had interaction more pronounced among female fetuses than male fetuses. Our suggested significant negative GDM, this may vary depending sex.