Association between blood ethylene oxide levels and periodontitis risk: a population-based study

• DOI: 10.3389/fpubh.2024.1338319
• Publication Date: 2024-02-07T05:30:01Z
• Authors: Yixuan Liu; Nuozhou Liu; Wei Xiong; Ruiyu Wang
• Keywords: Ethylene Oxide; Inflammation; etiology; ethylene oxide; Nutrition Surveys; Hemoglobins; 03 medical and health sciences; 0302 clinical medicine; NHANES; Humans; epidemiology; Public Health; Public aspects of medicine; RA1-1270; Periodontitis; periodontitis

Background The etiopathogenesis of periodontitis is closely associated with environmental conditions. However, the relationship between ethylene oxide exposure and risk remains unclear. Methods We selected qualified participants from National Health Nutrition Examination Survey (NHANES) 2013–2014. Periodontitis was identified according to criteria Community Periodontal Index (CPI), Centers for Disease Control Prevention (CDC)/American Academy Periodontology (AAP) definition. Ethylene quantified by hemoglobin adducts (HbEO) levels. Log2-transformation used normalize HbEO designed three logistic regression models explore potential periodontitis. Restricted cubic spline (RCS) subgroup analysis were also conducted all covariates adjusted. performed multivariable linear appraise association different indicators inflammation, including white blood cells, neutrophils, lymphocytes, monocytes. Mediation subsequently examine whether contributed development through systemic body inflammation. Results A total 1,065 aged more than 30 incorporated in this study. that higher levels showed increased after adjusting (OR = 1.49, 95% CI: 1.14, 1.95, p 0.0014). results remained stable. restricted curve revealed a non-linear correlation log2-transformed ( nonlinear < 0.001). indicated level significantly four inflammatory mediators, mediated proportions 14.44% 0.001) cell, 9.62% neutrophil, 6.17% 0.006) lymphocyte, 6.72% monocyte. Conclusion Participants periodontitis, which partially More well-designed longitudinal studies should be carried out validate relationship.