Nasal carriage rate, associated factors, and antimicrobial susceptibility patterns of methicillin resistance Staphylococcus aureus among pre-clinical undergraduate students at the College of Health and Medical Sciences, Haramaya University, Ethiopia

• DOI: 10.3389/fpubh.2024.1354461
• Publication Date: 2024-05-23T13:27:51Z
• Authors: Fitsum Weldegebreal; Kedir Urgesa; Firayad Ayele; Kasahun Bogale; Taddese Shume; Mohammed Ahmed; Sileshi Debebe; Fikru Tebeje; Haftu Asmerom; Tewodros Tesfa; Shambel Mekonnen
• Keywords: Carriage

Background Staphylococcus aureus nasal carriage has been linked to higher rates of infection and morbidity. People with Methicillin-resistant can be a potential source for others. University students living together in crowded conditions increase their risk acquiring infections. The prevalence S. , particularly carriage, Ethiopian university is sparse. Objective This study aimed determine the rate, associated factors, antimicrobial susceptibility patterns methicillin-resistant among pre-clinical at College Health Medical Sciences, Haramaya University, Ethiopia, from 1 July 30 August 2022. Methods An institutional-based cross-sectional was conducted 270 randomly selected Sciences students. Data on factors were collected using pre-tested, structured questionnaires. A swab taken each participant sent microbiology laboratory via Amies transport media cold chain. There, it cultivated conventional techniques. isolated colonies found its performed Kirby–Bauer disk diffusion method Muller–Hinton agar. expressing cefoxitin based CLSI breakpoint. entered into Epi-Data version 4.4.2.1 exported Statistical Package Social (SPSS) software 25 analysis. Pearson’s chi-square test predict associations between variables. p -value less than 0.05 regarded as statistically significant. Result 5.9% (95% CI: 3.09–8.7) cases colonization, which 12.96% 8.85–16.96). colonization significantly history cigarette smoking ( = 0.000), intake khat 0.042), nose-picking habit 0.003), sharing personal goods 0.021), hospitalizations 0.00). All isolates resistant ampicillin cefoxitin. Conclusion Based findings, considerable proportion healthy harbored strains behavioral factors. Furthermore, these showed high resistance ampicillin. Hence, crucial regularly prevent endogenous infections spread .