Differentiating COVID-19 and influenza in children: hemogram parameters as diagnostic tools

• DOI: 10.3389/fpubh.2024.1377785
• Publication Date: 2024-07-11T04:38:20Z
• Authors: Ramazan Dulkadir; Bahar Oztelcan Gu...
• Keywords: Male; 0301 basic medicine; Adolescent; SARS-CoV-2; differences; COVID-19 pandemic; COVID-19; Infant; Monocytes; Diagnosis, Differential; Eosinophils; Leukocyte Count; 03 medical and health sciences; ROC Curve; Child, Preschool; laboratory parameters; Influenza, Human; Humans; Female; Public Health; Public aspects of medicine; RA1-1270; influenza; Child

IntroductionIt is not always possible to differentiate between influenza and COVID-19 based on symptoms alone. This is a topic of significant importance as it aims to determine whether there are specific hematological parameters that can be used to distinguish between influenza and COVID-19 in children.MethodologyTwo hundred thirty-one children between the ages of 1 month and 18 years who presented to the children’s outpatient clinic between June 2021 and June 2022 with similar symptoms and were tested with an influenza test and a COVID-19 PCR test were included in the study. Of the patients included in the study, 130 tested positive for COVID-19 and 101 positive for influenza. The patients were evaluated for hematological parameters.ResultsAge, eosinophils and monocyte factors were shown to be statistically significantly effective in COVID-19. The risk of COVID-19 increased 1,484-fold with age, 10,708-fold with increasing eosinophil count, and 1,591-fold with increasing monocyte count. The performance of the monocyte count and eosinophil count was assessed by receiver operating characteristic curve (ROC) analysis. According to the performed ROC analysis, the area under the curve (AUC) value was observed to be 0.990 for monocytes. According to the cutoff point >1.50, the sensitivity value was determined as 98.4% and the specificity value as 97.0%. AUC significance for eosinophils was found to be 0.989. According to the cutoff point >0.02, the sensitivity value was determined as 99.2% and the specificity value as 93.1%.ConclusionIn the diagnosis of COVID-19, the eosinophil count and monocyte count are easily accessible, inexpensive, and important parameters in terms of differential diagnosis and can help in the differentiation of COVID-19 from influenza during seasonal outbreaks of the latter. Developing parameters for clinicians to use in diagnosing COVID-19 and influenza can facilitate their work in practice.