Impact of dioxins on reproductive health in female mammals

• DOI: 10.3389/ftox.2024.1392257
• Publication Date: 2024-05-07T04:31:52Z
• Authors: Nour Aldeli; Denis Murphy; Abdulsamie Hanano
• Keywords: Reproductive toxicity; Reproductive system

Extensive research has been conducted to investigate the toxicological impact of dioxins on mammals, revealing profound effects female reproductive system in both humans and animals. Dioxin exposure significantly disrupts intricate functions ovary, a pivotal organ responsible for endocrine processes. This disruption manifests as infertility, premature ovarian failure, disturbances sex steroid hormone levels. Comprehensive studies, encompassing accidental human experimental animal data, have raised wealth information with consistent yet varied conclusion influenced by factors. review begins providing an overarching background emphasizing its fundamental role health, particularly steroidogenesis receptor regulation. Subsequently, detailed examination Aryl hydrocarbon Receptor (AhR) governing function is presented. The then outlines sources toxicity dioxins, specific focus AhR involvement mediating mammals. Within this context, notably 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), Folliculogenesis Preimplantation embryos discussed. Furthermore, delves into disruptions hormonal caused TCDD their ramifications endometriosis. Notably, variations are highlighted relation dose, species, age. As forward-looking perspective, questions arise regarding potential molecular mechanisms beyond dioxins.