Phenotypic characterization of idiopathic epilepsy and epilepsy of unknown cause in Irish Setters

• DOI: 10.3389/fvets.2022.1066094
• Publication Date: 2022-12-12T00:33:36Z
• Authors: Marta Plonek; Montse M. Diaz-Es...; Quirine E. M. Sta...; Koen M. Santifort; Peter A. J. Leegw...; Paul J. J. Mandigers
• Keywords: Seizure types

Canine epileptic seizures are common neurological symptom presenting to veterinary practice. Idiopathic epilepsy (IE) with a suspected genetic background has been reported in several dog breeds. Although it the Irish Setter (IS), phenotypic characteristics have not yet described. The aim of this study was characterize phenotype IE breed and trace its mode inheritance. Owners IS were requested fill questionnaire via Dutch Club concerning their dogs. data assessed retrospectively using descriptive statistics. Forty-eight privately owned dogs fulfilling tier I criteria for according International Veterinary Epilepsy Task Force both sexes included study. mean age seizure onset 41 months. Five had an >6 years age. These classified unknown cause (EUC). Primary generalized tonic-clonic most type seen almost all Cluster 54% studied population. Most owners pre- (56%) post-ictal (97%) signs A pedigree analysis one subpopulation performed traced lineage 13 affected IS. segregation population rejected simple autosomal recessive inheritance pattern. present supports occurrence EUC results provide clinical insight into may be starting point further, including genetic, analysis.