Erythritol alters phosphotransferase gene expression and inhibits the in vitro growth of Staphylococcus coagulans isolated from canines with pyoderma

• DOI: 10.3389/fvets.2023.1272595
• Publication Date: 2024-01-04T05:02:50Z
• Authors: Saki Onishi-Sakamoto; Tadashi Fujii; Keito Watanabe; Reina Makida; Keita Iyori; Yoichi Toyoda; Takumi Tochio; Koji Nishifuji
• Keywords: Erythritol; Growth inhibition

Staphylococcus coagulans (SC) belongs to a group of coagulase-positive staphylococci occasionally isolated from the skin lesions dogs with pyoderma. We recently revealed that erythritol, sugar alcohol, inhibited growth SC strain JCM7470. This study investigated molecular mechanisms involved in this inhibition JCM7470 by and determine whether erythritol inhibits Comprehensive analysis gene expression presence upregulated glcB ptsG genes, both which encode phosphotransferase system (PTS) glucoside- glucose-specific permease C, B, A domains (EIICBA), respectively, associated uptake. Moreover, suppressed vitro all 27 strains canine pyoderma, including 13 mecA gene-positive 14 gene-negative strains. Finally, clinical isolates was restored addition glucose. In summary, we promotes PTS suppresses Restoration erythritol-induced glucose suggested starvation may contribute SC.