Bioactive Glass as a Nanoporous Drug Delivery System for Teicoplanin

• DOI: 10.3390/app10072595
• Publication Date: 2020-04-09T18:42:03Z
• Authors: Chih-Ling Huang; Wei Fang; Bo-Rui Huang; Yan-Hsiung Wang; Guo-Chung Dong; Tzer-Min Lee
• Keywords: Simulated body fluid; Nanoporous; Bioactive Glass

Bioactive glass (BG) was made by the sol–gel method and doped with boron (B) to increase its bioactivity. Microstructures of BG B-doped were observed scanning electron microscopy, phase identification performed using an X-ray diffraction diffractometer. The ion concentrations released after soaking in simulated body fluid (SBF) for 1, 4, 7 days measured inductively coupled plasma mass spectrometry, pH value SBF samples determine variation environment. Brunauer–Emmett–Teller (BET) analysis further verify characteristics mesoporous structures. High performance liquid chromatography used evaluate drug delivery ability teicoplanin. Results demonstrated that significantly better than parameters assessed BET analysis. has nanopores more rough structures, which is advantageous as there are porous structures available adsorption. Moreover, shown be effective keeping values stable releasing B ions during SBF. cumulative release teicoplanin from reached 20.09% 3.17% on first day, respectively. gradually slowed, reaching 29.43% 4.83% days, results demonstrate proposed bioactive potential a system.