3D Printed Piezoelectric BaTiO3/Polyhydroxybutyrate Nanocomposite Scaffolds for Bone Tissue Engineering

• DOI: 10.3390/bioengineering11020193
• Publication Date: 2024-02-19T10:39:56Z
• Authors: Giovanna Strangis; Massimiliano Labardi; Giuseppe Gallone; Mario Milazzo; Simone Capaccioli; Francesca Forli; Patrizia Cinelli; Stefano Berrettini; Maurizia Seggiani; Serena Danti; Paolo Parchi
• Keywords: Biomaterial; Polyhydroxybutyrate; Barium titanate; Bone tissue

Bone defects are a significant health problem worldwide. Novel treatment approaches in the tissue engineering field rely on use of biomaterial scaffolds to stimulate and guide regeneration damaged that cannot repair or regrow spontaneously. This work aimed at developing characterizing new piezoelectric provide electric bio-signals naturally present bone vascular tissues. Mixing extrusion were used obtain nanocomposites made polyhydroxybutyrate (PHB) as matrix barium titanate (BaTiO3) nanoparticles filler, BaTiO3/PHB compositions 5/95, 10/90, 15/85 20/80 (w/w%). The morphological, thermal, mechanical properties studied. Scanning electron microscopy analysis showed good nanoparticle dispersion within polymer matrix. Considerable increases Young’s modulus, compressive strength coefficient d31 observed with increasing BaTiO3 content, = 37 pm/V (w/w%) BaTiO3/PHB. 3D printing was produce porous cubic-shaped using 90° lay-down pattern, pore size ranging 0.60–0.77 mm stability. Biodegradation tests conducted for 8 weeks saline solution °C low mass loss (∼4%) printed scaffolds. results obtained terms piezoelectric, chemical nanocomposite promising strategy vascularized engineering.