Extreme Serum Titanium Concentration Induced by Acetabular Cup Failure: Unveiling a Unique Scenario of Titanium Alloy Debris Accumulation

• DOI: 10.3390/bioengineering11030235
• Publication Date: 2024-02-28T11:14:22Z
• Authors: Samo K. Fokter; Živa Ledinek; Milka Kljaić Dujić; Igor Novak
• Keywords: Groin; Titanium alloy

The majority of contemporary total hip arthroplasty (THA) implants are constructed from Ti alloys, which generally believed to generate fewer adverse local tissue reactions (ALTRs) compared CoCr alloys. This study presents a case unusual primary THA failure where substantial release alloy debris was observed. A 52-year-old active male underwent after post-traumatic aseptic necrosis the femoral head in 2006. Seventeen years procedure, patient presented with groin pain and restricted range motion. X-rays revealed protrusion alumina ceramic through Ti6Al4V acetabular cup. Trace element analysis indicated significantly elevated levels serum Ti, Al, V. CT MRI confirmed cup severe ALTR. During revision surgery, it found that worn-out direct contact cup, having protruded central hole had created over time. No liner found. Histological his samples showed wear-induced synovitis areas multinucleated foreign body giant cells accumulation numerous metal particles but no acute inflammatory response. Six months THA, has experienced favourable outcomes. provides an instructive illustration for studying consequences orthopedic implants.