Levetiracetam Reduced the Basal Excitability of the Dentate Gyrus without Restoring Impaired Synaptic Plasticity in Rats with Temporal Lobe Epilepsy

• DOI: 10.3390/brainsci10090634
• Publication Date: 2020-09-11T13:05:16Z
• Authors: Guillermo González-H; Itzel Jatziri Con...; Karla Sánchez-Huerta; Claudio M. T. Que...; Luis Ricardo Gall...; Julieta G. Mendoz...; Sergio R. Zamudio
• Keywords: Neural facilitation; Population spike

Temporal lobe epilepsy (TLE), the most common type of focal epilepsy, affects learning and memory; these effects are thought to emerge from changes in synaptic plasticity. Levetiracetam (LEV) is a widely used antiepileptic drug that also associated with reversal cognitive dysfunction. The long-lasting effect LEV treatment its participation plasticity have not been explored early chronic epilepsy. Therefore, through measurement evoked field potentials, this study aimed comprehensively identify alterations excitability short-term (depression/facilitation) long-term (long-term potentiation, LTP) dentate gyrus hippocampus lithium-pilocarpine rat model TLE, as well their possible restoration by (1 week; 300 mg/kg/day). TLE increased population spike (PS) amplitude (input/output curve); interestingly, partially reduced hyperexcitability. Furthermore, augmented depression, suppressed paired-pulse facilitation, PS-LTP; however, did alleviate such alterations. Conversely, excitatory postsynaptic potential (EPSP)-LTP rats was comparable control decreased LEV. caused attenuation basal hyperexcitability but restore impaired phase TLE.